BIOMARKERS IDENTIFICATION AND THERAPY TARGET IN MACROPHAGE OF ATHEROSCLEROSIS: SYSTEMATIC REVIEW

Macrophages are known to play an important role in the initiation and progression of atherosclerosis; however, molecular signaling pathways macrophages that responsible for plaque rupture have not been fully identified. This study aims identify biomarkers therapy targets atherosclerotic conditions by systematic review. Research procedure reviews using PRISMA protocol. The search engine used this is PubMed, with keywords ([macrophage] AND atherosclerosis) (signaling pathway OR pathway), reference application Zotero screen clinical articles. There were 689 articles identified 11 inclusion criteria obtained. identification resulted 30 associated conditions. proposed atherosclerosis interleukin (IL)-1β IL-18. potential LOX-1 schematic images plaques.